Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Nature Communications

September 2023

Gut Microbiota–Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms


April 2023

Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis

European Heart Journal

March 2023

Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension


July 2021

Gut Microbiota-Derived Trimethylamine N-Oxide and Kidney Function: A Systematic Review and Meta-Analysis

American Society for Nutrition

May 2021

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms


October 2020

Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulo…

Basic Sciences

May 2020

Development Of A Gut Microbe–Targeted Nonlethal Therapeutic To Inhibit Thrombosis Potential

Nature Medicine

September 2018

Advanced Chronic Kidney Disease Populations Have Elevated Trimethylamine N-Oxide Levels Associated With Increased Cardiovascular Events

May 2016

Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden

J Am Soc Nephrol

May 2016

Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease


January 2016

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Circulation Research

September 2014

A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

J Am Soc Nephrol

May 2013

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

Massachusetts Medical Society

April 2013

Gut Flora Metabolism Of Phosphatidylcholine Promotes Cardiovascular Disease


April 2011